Development of Manufacturing Processes for the Carboxylic Acid Key Intermediate of Lusutrombopag: One-Pot Reaction Process of Formylation and the Horner–Wadsworth

Development of Manufacturing Processes for the Carboxylic Acid Key Intermediate of Lusutrombopag: One-Pot Reaction Process of Formylation and the Horner–Wadsworth–Emmons Reaction

Published:2020-09-22 Issue:11 Volume:24 Page:2651-2656
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Matsuura Takaharu¹^ORCID,Sato Yusuke²,Nishino Yutaka²,Komurasaki Tadafumi³,Imamura Yoshiaki⁴,Kakinuma Makoto²

Affiliation:

1. API R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

2. Production Technology Department, Shionogi Pharma Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

3. Corporate Strategy Division, Shionogi and Co., Ltd., 2F, Nissay Yodoyabashi East, 3-13, Imabashi 3-chome, Chuo-ku, Osaka 541-0042, Japan

4. Analytical R&D Laboratory, CMC R&D Division, Shionogi and Co., Ltd., 1-3, Kuise Terajima 2-chome, Amagasaki, Hyogo 660-0813, Japan

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.0c00311

Reference15 articles.

1. a.

2. Takayama, M.; Kurose, N. Pharmaceutical Composition Containing Optically Active Compound Having Thrombopoietin Receptor Agonist Activity and Intermediate thereof.WO2009017098 A1.

3. bFukui, Y.; Maegawa, Y.; Matsuura, T.; Kurita, T. Preparation of High-purity Crystals of Optically Active Compounds as Thrombopoietin Receptor Agonists and Their Intermediates. WO2015093586 A12015.

4. Moore, S. Preparation of (pyrazolidenehydrazino)[1,1′-biphenyl]-3-carboxylates as TPO Receptor Agonists for Enhancing Platelet Production.WO2003098992 A2.

5. Sugasawa, K.; Watanuki, S.; Koga, Y.; Nagata, H.; Obitsu, K.; Wakayama, R.; Hirayama, F.; Suzuki, K. Preparation of 2-acylaminothiazole Derivatives or Salts Thereof as c-Mpl Receptor Ligands.WO2003062233 A1.

Cited by 3 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The First GMP Synthesis of MK-2118, a Small Molecule Agonist for Stimulator of Interferon Genes;Organic Process Research & Development;2024-05-30

2. Facile Synthesis and First Antifungal Exploration of Tetracyclic Meroterpenoids: (+)-Aureol, (−)-Pelorol, and Its Analogs;Journal of Natural Products;2024-04-01

3. Efficient Synthesis of Acrylates Bearing an Aryl or Heteroaryl Moiety: One-Pot Method from Aromatics and Heteroaromatics Using Formylation and the Horner-Wadsworth-Emmons Reaction;HETEROCYCLES;2021