Process Development and Scale-Up of a Benzoxazepine-Containing Kinase Inhibitor

Author:

Naganathan Sriram1,Andersen Denise L.1,Andersen Neil G.1,Lau Stephen1,Lohse Anders2,Sørensen Mads Detlef2

Affiliation:

1. Exelixis, Inc., 210 East Grand Avenue, South San Francisco, California 94080, United States

2. Niels Clauson-Kaas A/S, Rugmarken 28, Farum DK-3520, Denmark

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference38 articles.

1. PI3K and cancer: lessons, challenges and opportunities

2. Anand, N.;Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of their Use and Manufacture. U.S. Patent 8,648,066, Feb 11, 2014.

3. Aay, N.;Benzoxazepines as Inhibitors of PI3K/mTOR and Methods of their Use and Manufacture. U.S. Patent 8,637,499, Jan 28, 2014.

4. Synthesis, SAR studies, and evaluation of 1,4-benzoxazepine derivatives as selective 5-HT1A receptor agonists with neuroprotective effect: Discovery of Piclozotan

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