Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)-Reference-Cited by-同舟云学术

Development of a Scalable Asymmetric Process for the Synthesis of GLYT1 Inhibitor BI 425809 (Iclepertin)

Published:2023-03-03 Issue:3 Volume:27 Page:505-512
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Frutos Rogelio¹^ORCID,Tampone Thomas G.¹,Mulder Jason¹^ORCID,Gao Joe¹,Sieber Joshua D.¹^ORCID,Rodriguez Sonia¹^ORCID,Haddad Nizar¹^ORCID,Baer Katrin¹,Brown Jack¹,Yang Bing-Shiou¹,Giovannini Riccardo¹,Song Jinhua J.¹,Grinberg Nelu¹,Lee Heewon¹,Senanayake Chris H.¹

Affiliation:

1. Department of Chemical Development, Boehringer Ingelheim Pharmaceuticals, Inc., 900 Ridgebury Road, P.O. Box 368, Ridgefield, Connecticut 06877-0368, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00373

Reference15 articles.

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3. Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study

4. Enantiomerically Pure Synthesis of β-Substituted γ-Butyrolactones: A Key Intermediate to Concise Synthesis of Pregabalin

5. Alvaro, G.; Cardullo, F.; Castiglioni, E. Piperidine Based Ureas as NK1 Antagonists. Patent WO 2010007032 A1, 2010.

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