Early Process Development of a Squaramide-Based CXCR2 Receptor Antagonist

Author:

Martin Benjamin1,Lai Xinzhong2,Baettig Urs3,Neumann Eva1,Kuhnle Thomas1,Porter David3,Robinson Richard3,Hatto Julia3,D’Souza Anne-Marie3,Steward Oliver3,Watson Simon3,Press Neil J.3

Affiliation:

1. Novartis Pharma AG, Fabrikstrasse 14, 4002 Basel, Switzerland

2. Suzhou Novartis Pharma Technology Company Limited, Changshu, Jiangsu 215537, China

3. Novartis Pharmaceuticals UK Limited, Wimblehurst Road, Horsham Sussex RH12 5AB, United Kingdom

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference18 articles.

1. Chronic obstructive pulmonary disease (COPD), Fact sheet No. 315:World Health Organization, 2013.http://www.who.int/mediacentre/factsheets/fs315/en/(accessed 15 Jan, 2015) .

2. Chronic obstructive pulmonary disease: current burden and future projections

3. Assignment of the genes encoding human interleukin-8 receptor types 1 and 2 and an interleukin-8 receptor pseudogene to chromosome 2q35

4. aBaettig, U.; D’Souza, A.M.; Hunt, P.; Press, N. J.; Watson, S. J.Organic Compounds. US 2010/0029670 Al, 2010.

5. bAmbarkhane, A. V.; Mauler, A.; Timpe, C.; Baettig, U.Choline salt of an anti-inflammatory substituted cyclobutenedione compound. WO 2013/030803 A1, 2013.

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