Two Approaches to a Trifluoromethyl Triazole: A Fit-for-Purpose Trifluoromethylation in Flow-Mode and a Long-Term Decarboxylative Click Approach-Reference-Cited by-同舟云学术

Two Approaches to a Trifluoromethyl Triazole: A Fit-for-Purpose Trifluoromethylation in Flow-Mode and a Long-Term Decarboxylative Click Approach

Published:2020-02-10 Issue:2 Volume:24 Page:207-215
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Ayothiraman Rajaram¹,Gangu Aravind S.¹,Bandaru Durgarao¹,Guturi Siva Krishna¹,Lakshminarasimhan Thirumalai¹,Jaleel Mohamed¹,Kanagavel Kishorekumar¹,Rangaswamy Sundaramurthy¹,Cuniere Nicolas L.²,Zaretsky Serge²,Camacho Kathryn²,Eastgate Martin D.²^ORCID,Vaidyanathan Rajappa¹^ORCID

Affiliation:

1. Chemical Development and API Supply, Biocon Bristol-Myers Squibb Research and Development Center, Biocon Park, Jigani Link Road, Bommasandra IV, Bengaluru 560099, India

2. Chemical and Synthetic Development, Bristol-Myers Squibb, 1 Squibb Drive, New Brunswick, New Jersey 08903, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.9b00492

Reference24 articles.

1. Panja, C.; Puttaramu, J. V.; Chandra, T. K.; Nimje, R. Y.; Kumar, H.; Gupta, A.; Arunachalam, P. N.; Mathur, A. Methyl-2,2-difluoro-2-(fluorosulfonyl) acetate (MDFA)/Copper (I) Iodide Mediated and Tetrabutylammonium Iodide Promoted Trifluoromethylation of 1-Aryl-4-Iodo-1,2,3-Triazoles, unpublished results.

2. Strategies for nucleophilic, electrophilic, and radical trifluoromethylations

3. Recent Advances in Trifluoromethylation Reactions with Electrophilic Trifluoromethylating Reagents

4. Progress in copper-catalyzed trifluoromethylation

5. Fluoroalkylation reactions in aqueous media: a review

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