<i>tert</i>-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure-Reference-Cited by-同舟云学术

tert-Butylethylcarbodiimide as an Efficient Substitute for Diisopropylcarbodiimide in Solid-Phase Peptide Synthesis: Understanding the Side Reaction of Carbodiimides with OxymaPure

Published:2022-09-09 Issue:10 Volume:26 Page:2894-2899
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Manne Srinivasa Rao¹,Akintayo Damilola Caleb¹,Luna Omar²³,El-Faham Ayman⁴,de la Torre Beatriz G.¹⁵^ORCID,Albericio Fernando¹²³^ORCID

Affiliation:

1. Peptide Science Laboratory, School of Chemistry and Physics, University of KwaZulu-Natal, Westville, Durban 4000, South Africa

2. CIBER-BBN, Networking Centre on Bioengineering, Biomaterials and Nanomedicine, and Department of Organic Chemistry, University of Barcelona, 08028 Barcelona, Spain

3. Institute for Advanced Chemistry of Catalonia (IQAC-CSIC), 08034 Barcelona, Spain

4. Department of Chemistry, Faculty of Science, Alexandria University, Ibrahimia, Alexandria 21321, Egypt

5. KwaZulu-Natal Research Innovation and Sequencing Platform (KRISP), School of Laboratory Medicine and Medical Sciences, College of Health Sciences, University of KwaZulu-Natal, Durban 4041, South Africa

Funder

South African Agency for Science and Technology Advancement

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.2c00220

Reference28 articles.

1. Water: An Underestimated Solvent for Amide Bond-Forming Reactions

2. Evaluation of alternative solvents in common amide coupling reactions: replacement of dichloromethane and N,N-dimethylformamide

3. Amide bond formation and peptide coupling