Development of a Thiophosphorylation Process for the Synthesis of 2′F-Thio-Adenosine Monophosphate
Author:
Affiliation:
1. Department of Process Research and Development, Merck & Co., Inc., 126 E. Lincoln Avenue, Rahway, New Jersey 07065, United States
Publisher
American Chemical Society (ACS)
Link
https://pubs.acs.org/doi/pdf/10.1021/acs.oprd.3c00429
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1. STING is a direct innate immune sensor of cyclic di-GMP
2. Discovery of MK-1454: A Potent Cyclic Dinucleotide Stimulator of Interferon Genes Agonist for the Treatment of Cancer
3. A kinase-cGAS cascade to synthesize a therapeutic STING activator
4. Diverse Catalytic Reactions for the Stereoselective Synthesis of Cyclic Dinucleotide MK-1454
5. Investigation of Enzyme Mechanisms with Nucleoside Phosphorothioates
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