Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept-Reference-Cited by-同舟云学术

Synthesis of Vixotrigine, a Use-Dependent Sodium Channel Blocker. Part 1: Development of Bulk Supply Routes to Enable Proof of Concept

Author:

Giblin Gerard¹,Heseltine Adrian²,Kiesman William³,MacPherson David¹,Ramsden James⁴,Vadali Ravi⁵,Williams Michael¹,Witty David¹^ORCID

Affiliation:

1. Convergence Pharmaceuticals (a Biogen Company), Babraham Research Campus, Cambridge CB22 3AT, U.K.

2. Dr. Reddy’s Laboratories (EU) Limited, Steanard Lane, Mirfield, West Yorkshire WF14 8HZ, U.K.

3. Biogen Inc., 225 Binney Street, Cambridge, Massachusetts 02142, United States

4. Dr. Reddy’s Laboratories (EU) Limited, 410 Cambridge Science Park Milton Road, Cambridge CB4 0PE, U.K.

5. Dr. Reddy’s Laboratories Ltd., Hyderabad 500049, Telangana, India

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

Reference19 articles.

5. Alvaro, G.; Bergauer, M.; Giovannini, R.; Profeta, R. Prolinamide derivatives as sodium channel modulators. WO2007042239A12007.

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