Dual Angiotensin II and Endothelin A Receptor Antagonists:  Synthesis of 2‘-Substituted N-3-Isoxazolyl Biphenylsulfonamides with Improved Potency and Pharmacokinetics

Author:

Murugesan Natesan1,Gu Zhengxiang1,Fadnis Leena1,Tellew John E.1,Baska Rose Ann F.1,Yang Yifan1,Beyer Sophie M.1,Monshizadegan Hossain1,Dickinson Kenneth E.1,Valentine Maria T.1,Humphreys W. Griffith1,Lan Shih-Jung1,Ewing William R.1,Carlson Kenneth E.1,Kowala Mark C.1,Zahler Robert1,Macor John E.1

Affiliation:

1. Discovery Chemistry and Metabolic and Cardiovascular Drug Discovery, Bristol-Myers Squibb Pharmaceutical Research Institute, Princeton, New Jersey 08543-5400

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

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