1. Departments of Medicinal Chemistry and DMPK, Cardiovascular and Urogenital Centre of Excellence for Drug Discovery, GlaxoSmithKline Research and Development, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, U.K., Department of Assay Development and Compound Profiling, GlaxoSmithKline, New Frontiers, Science Park, Third Avenue, Harlow, Essex, CM19 5AD, U.K., and Safety Assessment, GlaxoSmithKline, Ware, Herts, SG12 0DP, U.K.