Synthesis and Evaluation of 11β-Substituted 21-Chloro/Iodo-(17α,20E/Z)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols: High-Affinity Ligands for the Estrogen Receptor-Reference-Cited by-同舟云学术

Synthesis and Evaluation of 11β-Substituted 21-Chloro/Iodo-(17α,20E/Z)-19-norpregna-1,3,5(10),20-tetraene-3,17β-diols: High-Affinity Ligands for the Estrogen Receptor

Published:1998-10-24 Issue:24 Volume:41 Page:4686-4692
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Hanson Robert N.¹,Napolitano Elio¹,Fiaschi Rita¹

Affiliation:

1. Department of Pharmaceutical Sciences, Bouve College of Pharmacy and Health Sciences, Northeastern University, 360 Huntington Avenue, Boston, Massachusetts 02115, Scoula Normale Superiore, Piazza dei Cavalieri 7, 56100 Pisa, Italy, and Dipartimento di Chimica Bioorganica, Universita di Pisa, 56125 Pisa, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9801051

Reference20 articles.

1. Synthesis and estrogen receptor binding of novel 11.beta.-substituted estra-1,3,5(10)-triene-3,17.beta.-diols

2. Synthesis, radiolabeling and tissue distribution of 11β-fluoroalkyl- and 11β-fluoroalkoxy-substituted estrogens: Target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens

3. Electrophilic destannylation: stereospecific introduction of electrophiles at the 21 position of (17.alpha.)-19-norpregna-1,3,5(10),20-tetraene-3,17.beta.-diols

4. Structure-activity relationships of estrogenic ligands: synthesis and evaluation of (17.alpha.,20E)- and (17.alpha.,20Z)-21-halo-19-norpregna-1,3,5(10),20-tetraene-3,17.beta.-diols

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