New and Highly Efficient Synthesis of Cis- and Trans-Opened Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Adducts at the Exocyclic N2-Amino Group of Deoxyguanosine-Reference-Cited by-同舟云学术

New and Highly Efficient Synthesis of Cis- and Trans-Opened Benzo[a]pyrene 7,8-Diol 9,10-Epoxide Adducts at the Exocyclic N2-Amino Group of Deoxyguanosine

Published:2000-08-09 Issue:18 Volume:65 Page:5558-5564
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Kroth Heiko¹,Yagi Haruhiko¹,Seidel Albrecht¹,Jerina Donald M.¹

Affiliation:

1. Laboratory of Bioorganic Chemistry, National Institutes of Diabetes and Digestive and Kidney Diseases, The National Institutes of Health, Bethesda, Maryland 20892, and Biochemical Institute for Environmental Carcinogens, Lurup 4, D-22927 Grosshansdorf, Federal Republic of Germany

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo000522x

Reference56 articles.

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2. (a) Jerina, D. M.; Chadha, A.; Cheh, A. M. Schurdak, M. E.; Wood, A. W.; Sayer, J. M. InBiological Reactive Intermediates IV. Molecular andCellular Effects and Their Impact on Human Health; Witmer, C. M., Snyder, R., Jollow, D. J., Kalf, G. F., Kocsis, J. J., Sipes, I. G., Eds.; Plenum Press: New York, 1991; pp 533−553.

3. Activation of c-Ha-ras-1 proto-oncogene by in vitro modification with a chemical carcinogen, benzo(a)pyrene diol-epoxide

4. Mutations activating human c-Ha-ras1 protooncogene (HRAS1) induced by chemical carcinogens and depurination.

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