Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes-Reference-Cited by-同舟云学术

Novel (2E,4E,6Z)-7-(2-Alkoxy-3,5-dialkylbenzene)-3-methylocta-2,4,6-trienoic Acid Retinoid X Receptor Modulators Are Active in Models of Type 2 Diabetes

Published:2003-05-20 Issue:13 Volume:46 Page:2683-2696
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Michellys P. Y.¹,Ardecky R. J.¹,Chen J. H.¹,Crombie D. L.¹,Etgen G. J.¹,Faulkner A. L.¹,Faul M. M.¹,Grese T. A.¹,Heyman R. A.¹,Karanewsky D. S.¹,Klausing K.¹,Leibowitz M. D.¹,Liu S.¹,Mais D. A.¹,Mapes C. M.¹,Marschke K. B.¹,Reifel-Miller A.¹,Ogilvie K. M.¹,Rungta D.¹,Thompson A. W.¹,Tyhonas J. S.¹,Boehm M. F.¹

Affiliation:

1. Department of Medicinal Chemistry, Ligand Pharmaceuticals, Incorporated, 10275 Science Center Drive, San Diego, California 92121

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm020340q

Reference45 articles.

1. Orfanos, C. E. ; Ehlert, R. ; Gollnick, H. The Retinoids. A Review of Their Clinical Pharmacologyand Therapeutic Use. [Review] Drugs1987,34, 459−503.

2. Peck, G. L. ; DiGiovanna, J. J. ; Synthetic Retinoids in Dermatology. In TheRetinoids: Biology, Chemistry, and Medicine, 2nd ed.; Raven Press: New York, 1994; pp 631−658.

3. Section Review: Retinoids: Biological Function and Use in the Treatment of Dermatological Diseases: Pulmonary-Allergy, Dermatological, Gastrointestinal & Arthritis

4. The Intracellular Receptor and Signal Transducers and Activators of Transcription Factor Superfamilies: Novel Targets for Small-Molecule Drug Discovery

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