Efficient Synthesis of 8-Oxa-3-aza-bicyclo[3.2.1]octane Hydrochloride

Author:

Connolly Terrence J.1,Considine John L.1,Ding Zhixian1,Forsatz Brian1,Jennings Mellard N.1,MacEwan Michael F.1,McCoy Kevin M.1,Place David W.1,Sharma Archana1,Sutherland Karen1

Affiliation:

1. Chemical Development, Wyeth Research, 401 North Middletown Road, Pearl River, New York 10965, U.S.A.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Reference21 articles.

1. Early Process Development: The Wyeth Approach

2. Aminoalcohols Containing the 8-Oxa-3-azabicyclo [3.2.1]octane Ring System and Their Benzoates

3. 1. The conversion of sucrose into furan compounds. Part II. Some 2 : 5-disubstituted tetrahydrofurans and their products of ring scission

4. Screening was performed using an Endeavor Catalyst Screening System from Biotage/Argonaut.

5. 13C NMR supported the 95/5 ratio of isomers determined by GC. See theExperimental Sectionfor line listings of both the major and minor isomer.

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