4-Benzimidazolyl-3-Phenylbutanoic Acids As Novel Pif-Pocket-Targeting Allosteric Inhibitors of Protein Kinase PKCζ-Reference-Cited by-同舟云学术

4-Benzimidazolyl-3-Phenylbutanoic Acids As Novel Pif-Pocket-Targeting Allosteric Inhibitors of Protein Kinase PKCζ

Published:2011-09-14 Issue:19 Volume:54 Page:6714-6723
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Fröhner Wolfgang¹,Lopez-Garcia Laura A.²,Neimanis Sonja²,Weber Nadja¹,Navratil Jeanette²,Maurer Frauke³,Stroba Adriana¹,Zhang Hua²,Biondi Ricardo M.²,Engel Matthias¹

Affiliation:

1. Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 151150, D-66041 Saarbrücken, Germany

2. Department of Internal Medicine I, University of Frankfurt, Theodor-Stern-Kai 7, D-60590 Frankfurt a.M., Germany

3. Department of Organic Chemistry, Saarland University, P.O. Box 151150, D-66041 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm2005892

Reference48 articles.

1. Lopez-Garcia, L. A.; Schulze, J. O.; Fröhner, W.; Zhang, H.; Weber, N.; Navratil, J.; Amon, S.; Hindie, V.; Zeuzem, S.; Jørgensen, T. J. D.; Alzari, P. M.; Neimanis, S.; Engel, M.; Biondi, R. M.Allosteric regulation of protein kinase PKCzeta by the N-terminal C1 domain and small compounds to the PIF-pocket.Chem. Biol. 2011, in press.

2. Protein Kinase Czeta (PKCzeta): Activation Mechanisms and Cellular Functions

3. Protein Kinase C-λ Knockout in Embryonic Stem Cells and Adipocytes Impairs Insulin-Stimulated Glucose Transport

4. Targeted Disruption of the ζPKC Gene Results in the Impairment of the NF-κB Pathway

5. Role of zetaPKC in B-cell signaling and function

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