Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate-Reference-Cited by-同舟云学术

Discovery of N-(3-Fluorophenyl)-1-[(4-([(3S)-3-methyl-1-piperazinyl]methyl)phenyl)acetyl]-4-piperidinamine (GSK962040), the First Small Molecule Motilin Receptor Agonist Clinical Candidate

Published:2009-02-03 Issue:4 Volume:52 Page:1180-1189
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Westaway Susan M.¹,Brown Samantha L.¹,Fell Stephen C. M.¹,Johnson Christopher N.¹,MacPherson David T.¹,Mitchell Darren J.¹,Myatt James W.¹,Stanway Steven J.¹,Seal Jon T.¹,Stemp Geoffrey¹,Thompson Mervyn¹,Lawless Kirk¹,McKay Fiona¹,Muir Alison I.¹,Barford Jonathan M.¹,Cluff Chermaine¹,Mahmood Sadhia R.¹,Matthews Kim L.¹,Mohamed Shiyam¹,Smith Beverley¹,Stevens Alexander J.¹,Bolton Victoria J.¹,Jarvie Emma M.¹,Sanger Gareth J.¹

Affiliation:

1. Immuno-Inflammation Centre of Excellence for Drug Discovery, GlaxoSmithKline, Medicines Research Centre, Gunnels Wood Road, Stevenage, Herts, SG1 2NY, U.K., Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, CM19 5AW, U.K., and Molecular Discovery Research, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, CM19 5AW, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm801332q

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5. Receptor for Motilin Identified in the Human Gastrointestinal System

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