De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments-Reference-Cited by-同舟云学术

De Novo Design of Protein Kinase Inhibitors by in Silico Identification of Hinge Region-Binding Fragments

Published:2013-03-27 Issue:5 Volume:8 Page:1044-1052
ISSN:1554-8929
Container-title:ACS Chemical Biology
language:en
Short-container-title:ACS Chem. Biol.

Author:

Urich Robert¹,Wishart Grant²,Kiczun Michael²,Richters André³,Tidten-Luksch Naomi¹,Rauh Daniel³,Sherborne Brad²,Wyatt Paul G.¹,Brenk Ruth⁴

Affiliation:

1. Drug Discovery Unit (DDU), Division of Biological Chemistry and Drug Discovery, College of Life Sciences, University of Dundee, Sir James Black Centre, DD1 5EH, U.K.

2. Department of Chemistry, MSD, Newhouse, Lanarkshire, ML1 5SH, U.K.

3. Fakultät Chemie - Chemische Biologie, Technische Universität Dortmund, Otto-Hahn-Straße 6, 44227 Dortmund, Germany

4. Institut für Pharmazie und Biochemie, Johannes Gutenberg-Universität Mainz, Staudinger Weg 5, 55128 Mainz, Germany

Publisher

American Chemical Society (ACS)

Subject

Molecular Medicine,General Medicine,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/cb300729y

Reference46 articles.

1. Protein kinases — the major drug targets of the twenty-first century?

2. Kinase Drug Discovery – What’s Next in the Field?

3. A public-private partnership to unlock the untargeted kinome

4. Proteus in the World of Proteins: Conformational Changes in Protein Kinases

5. Insights into protein kinase regulation and inhibition by large scale structural comparison

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