1. Institute of Biotechnology, National Tsing Hua University, No. 101, Section 2 Kuang-Fu Road, Hsinchu, Taiwan, Republic of China; Graduate Institute of Biopharmaceutics, Life Science College, National Chiayi University, 300 University Road, Chiayi, Taiwan, Republic of China; and Department of Food and Nutrition and Research Institute of Biotechnology, Hung Kuang University, No. 34 Chung-Chie Road, Shalu County, Taichung Hsien, Taiwan, Republic of China