Intracellular Delivery of the Reactive Oxygen Species Generating Agent d-Penicillamine upon Conjugation to Poly-l-glutamic Acid-Reference-Cited by-同舟云学术

Intracellular Delivery of the Reactive Oxygen Species Generating Agent d-Penicillamine upon Conjugation to Poly-l-glutamic Acid

Published:2010-04-06 Issue:3 Volume:7 Page:854-862
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Wadhwa Saurabh¹,Mumper Russell J.¹

Affiliation:

1. Division of Molecular Pharmaceutics, UNC Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, North Carolina 27599-7362, Center for Nanotechnology in Drug Delivery, University of North Carolina at Chapel Hill, North Carolina 27599-7362, and UNC Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, North Carolina 27599-7295

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp1000058

Reference50 articles.

1. ROS stress in cancer cells and therapeutic implications

2. Elevated copper and oxidative stress in cancer cells as a target for cancer treatment

3. Copper chelation by D-penicillamine generates reactive oxygen species that are cytotoxic to human leukemia and breast cancer cells

4. An investigation into copper catalyzed D-penicillamine oxidation and subsequent hydrogen peroxide generation

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