Direct, Catalytic α-Alkylation of N-Heterocycles by Hydroaminoalkylation: Substrate Effects for Regiodivergent Product Formation
Author:
Affiliation:
1. Department of Chemistry, The University of British Columbia, 2036 Main Mall, Vancouver, BC, Canada V6T 1Z1
Funder
Canada Research Chairs
Universit??t Bern
Natural Sciences and Engineering Research Council of Canada
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/jacs.1c05498
Reference63 articles.
1. Analysis of the Structural Diversity, Substitution Patterns, and Frequency of Nitrogen Heterocycles among U.S. FDA Approved Pharmaceuticals
2. Recent trends in catalytic sp3 C–H functionalization of heterocycles
3. Transition metal-catalyzed arylation of unactivated C(sp3)–H bonds
4. Ligand‐Enabled Catalytic CH Arylation of Aliphatic Amines by a Four‐Membered‐Ring Cyclopalladation Pathway
5. Enantioselective amine α-functionalization via palladium-catalysed C–H arylation of thioamides
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