Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore-Reference-Cited by-同舟云学术

Redox Modifications in the Biosynthesis of Alchivemycin A Enable the Formation of Its Key Pharmacophore

Published:2021-03-18 Issue:12 Volume:143 Page:4751-4757
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Zhu Hong Jie¹,Zhang Bo¹,Wang Lan¹,Wang Wen¹,Liu Shuang He¹,Igarashi Yasuhiro²^ORCID,Bashiri Ghader³^ORCID,Tan Ren Xiang¹^ORCID,Ge Hui Ming¹^ORCID

Affiliation:

1. State Key Laboratory of Pharmaceutical Biotechnology, Institute of Functional Biomolecules, School of Life Sciences, Chemistry and Biomedicine Innovation Center (ChemBIC), Nanjing University, Nanjing 210023, China

2. Biotechnology Research Center and Department of Biotechnology, Toyama Prefectural University, Toyama 939-0398, Japan

3. Laboratory of Molecular and Microbial Biochemistry, School of Biological Sciences, The University of Auckland, Auckland 1010, New Zealand

Funder

Ministry of Education of the People's Republic of China

Ministry of Science and Technology of the People's Republic of China

Health Research Council of New Zealand

National Natural Science Foundation of China

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c00516

Reference32 articles.

1. Alchivemycin A, a Bioactive Polycyclic Polyketide with an Unprecedented Skeleton from Streptomyces sp.

2. Previously undescribed antioxidative azocinyl morpholinone alkaloid from red seaweed Gracilaria opuntia with anti-cyclooxygenase and lipoxygenase properties

3. Asaroidoxazines from the Roots of Asarum asaroides Induce Apoptosis in Human Neuroblastoma Cells

4. New C-3′ hydroxamate-substituted and more lipophilic cyclic hydroxamate cephalosporin derivatives as a potential new generation of selective antimicrobial agents

5. Studies towards the synthesis of the functionalized C3–C14 decalin framework of alchivemycin A

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