O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics-Reference-Cited by-同舟云学术

O-Linked-N-Acetylglucosaminylation of the RNA-Binding Protein EWS N-Terminal Low Complexity Region Reduces Phase Separation and Enhances Condensate Dynamics

Published:2021-07-26 Issue:30 Volume:143 Page:11520-11534
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nosella Michael L.¹²^ORCID,Tereshchenko Maria²,Pritišanac Iva¹²,Chong P. Andrew¹^ORCID,Toretsky Jeffrey A.³,Lee Hyun O.²,Forman-Kay Julie D.¹²^ORCID

Affiliation:

1. Molecular Medicine Program, The Hospital for Sick Children, Toronto, ON M5G 0A4, Canada

2. Department of Biochemistry, University of Toronto, Toronto, ON M5S 1A8, Canada

3. Departments of Oncology and Pediatrics, Georgetown University, Washington, D.C. 20057, United States

Funder

Canadian Institutes of Health Research

University of Toronto

National Cancer Institute

Canada Research Chairs

Children's Cancer Foundation

Natural Sciences and Engineering Research Council of Canada

Canadian Cancer Society

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c04194

Reference96 articles.

1. Biomolecular condensates: organizers of cellular biochemistry

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3. Protein Phase Separation: A New Phase in Cell Biology

4. Theories for Sequence-Dependent Phase Behaviors of Biomolecular Condensates

5. Polymer physics of intracellular phase transitions

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