A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN-Reference-Cited by-同舟云学术

A Remote Secondary Binding Pocket Promotes Heteromultivalent Targeting of DC-SIGN

Published:2021-11-08 Issue:45 Volume:143 Page:18977-18988
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Wawrzinek Robert¹,Wamhoff Eike-Christian¹²^ORCID,Lefebre Jonathan¹²,Rentzsch Mareike¹²,Bachem Gunnar³,Domeniconi Gary³,Schulze Jessica¹²,Fuchsberger Felix F.¹²,Zhang Hengxi¹²,Modenutti Carlos⁴,Schnirch Lennart¹²,Marti Marcelo A.⁴^ORCID,Schwardt Oliver⁵,Bräutigam Maria¹,Guberman Mónica¹,Hauck Dirk⁶⁷,Seeberger Peter H.¹²,Seitz Oliver³^ORCID,Titz Alexander⁶⁷⁸^ORCID,Ernst Beat⁵^ORCID,Rademacher Christoph¹²⁹¹⁰^ORCID

Affiliation:

1. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, 14424 Potsdam, Germany

2. Department of Chemistry and Biochemistry, Freie University of Berlin, 14195 Berlin, Germany

3. Department of Chemistry, Humboldt University of Berlin, 12489 Berlin, Germany

4. Departamento de Química Biológica e IQUIBICEN-CONICET, Universidad de Buenos Aires, C1428EHA Ciudad de Buenos Aires, Argentina

5. Department of Pharmaceutical Sciences, University of Basel, 4056 Basel, Switzerland

6. Chemical Biology of Carbohydrates, Helmholtz Institute for Pharmaceutical Research Saarland, Helmholtz Centre for Infection Research, 66123 Saarbrücken, Germany

7. German Centre for Infection Research, Campus Hannover-Braunschweig, 38124 Braunschweig, Germany

8. Department of Chemistry, Saarland University, 66123 Saarbrücken, Germany

9. University of Vienna, Department of Pharmaceutical Sciences, Althanstrasse 14, 1090 Vienna, Austria

10. University of Vienna, Department of Microbiology, Immunology and Genetics, Max F. Perutz Laboratories, Biocenter 5, 1030 Vienna, Austria

Funder

Deutscher Akademischer Austauschdienst

Deutsche Forschungsgemeinschaft

Boehringer Ingelheim Stiftung

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c07235

Reference72 articles.

1. The Biology and Underlying Mechanisms of Cross-Presentation of Exogenous Antigens on MHC-I Molecules

2. Cross-presentation of cell-associated antigens by MHC class I in dendritic cell subsets

3. Understanding the Biology of Antigen Cross-Presentation for the Design of Vaccines Against Cancer

4. Cross-presentation through langerin and DC-SIGN targeting requires different formulations of glycan-modified antigens

5. Dendritic-cell immunotherapy: from ex vivo loading to in vivo targeting

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