An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species-Reference-Cited by-同舟云学术

An Integrated Mass Spectrometry and Molecular Dynamics Simulations Approach Reveals the Spatial Organization Impact of Metal-Binding Sites on the Stability of Metal-Depleted Metallothionein-2 Species

Published:2021-09-03 Issue:40 Volume:143 Page:16486-16501
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Peris-Díaz Manuel David¹^ORCID,Guran Roman²³^ORCID,Domene Carmen⁴⁵^ORCID,de los Rios Vivian⁶,Zitka Ondrej²³^ORCID,Adam Vojtech²³^ORCID,Krężel Artur¹^ORCID

Affiliation:

1. Department of Chemical Biology, Faculty of Biotechnology, University of Wrocław, F. Joliot-Curie 14a, 50-383 Wrocław, Poland

2. Department of Chemistry and Biochemistry, Mendel University in Brno, Zemedelska 1, 613 00 Brno, Czech Republic

3. Central European Institute of Technology, Brno University of Technology, Purkynova 123, 612 00 Brno, Czech Republic

4. Department of Chemistry, University of Bath, Claverton Down, Bath BA2 7AY, United Kingdom

5. Department of Chemistry, University of Oxford, Oxford OX1 3TA, United Kingdom

6. Functional Proteomics, Department of Cellular and Molecular Medicine and Proteomic Facility, Centro de Investigaciones Biológicas (CIB-CSIC), Ramiro de Maeztu 9, 28040 Madrid, Spain

Funder

Narodowe Centrum Nauki

H2020 European Research Council

Central European Institute of Technology

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c05495

Reference87 articles.

1. The Functions of Metamorphic Metallothioneins in Zinc and Copper Metabolism