Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities-Reference-Cited by-同舟云学术

Design of BET Inhibitor Bottlebrush Prodrugs with Superior Efficacy and Devoid of Systemic Toxicities

Published:2021-03-19 Issue:12 Volume:143 Page:4714-4724
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Vohidov Farrukh¹,Andersen Jannik N.²,Economides Kyriakos D.²,Shipitsin Michail V.²,Burenkova Olga²,Ackley James C.²,Vangamudi Bhavatarini²,Nguyen Hung V.-T.¹^ORCID,Gallagher Nolan M.¹,Shieh Peyton¹,Golder Matthew R.¹^ORCID,Liu Jenny¹²,Dahlberg William K.²,Ehrlich Deborah J. C.¹,Kim Julie¹,Kristufek Samantha L.¹,Huh Sung Jin²,Neenan Allison M.²,Baddour Joelle²,Paramasivan Sattanathan²,de Stanchina Elisa³,KC Gaurab²,Turnquist David J.²,Saucier-Sawyer Jennifer K.²,Kopesky Paul W.²,Brady Samantha W.²,Jessel Michael J.²,Reiter Lawrence A.²,Chickering Donald E.²,Johnson Jeremiah A.¹^ORCID,Blume-Jensen Peter²

Affiliation:

1. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

2. XTuit Pharmaceuticals, 35 Gatehouse Drive, Waltham, Massachusetts 02451, United States

3. Memorial Sloan Kettering Cancer Center, 417 E 68th St, New York, New York 10065, United States

Funder

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.1c00312