Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry-Reference-Cited by-同舟云学术

Single Mutation on Trastuzumab Modulates the Stability of Antibody–Drug Conjugates Built Using Acetal-Based Linkers and Thiol-Maleimide Chemistry

Published:2022-03-16 Issue:12 Volume:144 Page:5284-5294
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Ferhati Xhenti¹,Jiménez-Moreno Ester¹^ORCID,Hoyt Emily A.²^ORCID,Salluce Giulia²^ORCID,Cabeza-Cabrerizo Mar²,Navo Claudio D.³^ORCID,Compañón Ismael¹,Akkapeddi Padma⁴,Matos Maria J.²^ORCID,Salaverri Noelia¹,Garrido Pablo⁵^ORCID,Martínez Alfredo⁵^ORCID,Laserna Víctor⁶,Murray Thomas V.⁶,Jiménez-Osés Gonzalo³⁷^ORCID,Ravn Peter⁶,Bernardes Gonçalo J. L.²⁴^ORCID,Corzana Francisco¹^ORCID

Affiliation:

1. Departamento de Química, Centro de Investigación en Síntesis Química, Universidad de La Rioja, 26006 Logroño, Spain

2. Yusuf Hamied Department of Chemistry, University of Cambridge, Lensfield Road, CB2 1EW Cambridge, U.K.

3. Center for Cooperative Research in Biosciences (CIC BioGUNE), Basque Research and Technology Alliance (BRTA), Bizkaia Technology Park, Building 800, 48160 Derio, Spain

4. Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal

5. Angiogenesis Group, Oncology Area, Center for Biomedical Research of La Rioja (CIBIR), 26006 Logroño, Spain

6. Biologics Engineering, R&D, Astra Zeneca, CB21 6GH Cambridge, U.K.

7. Ikerbasque, Basque Foundation for Science, 48013 Bilbao, Spain

Funder

Ministerio de Ciencia, Innovación y Universidades

Ministerio de Economía y Competitividad

H2020 Marie Sklodowska-Curie Actions

Xunta de Galicia

Universidad de La Rioja

Agencia Estatal Investigation

Publisher