Discovery of Di- and Trihaloacetamides as Covalent SARS-CoV-2 Main Protease Inhibitors with High Target Specificity

Author:

Ma Chunlong1,Xia Zilei1,Sacco Michael Dominic2,Hu Yanmei1,Townsend Julia Alma3,Meng Xiangzhi4,Choza Juliana1,Tan Haozhou1,Jang Janice1,Gongora Maura V.2,Zhang Xiujun2,Zhang Fushun4,Xiang Yan4,Marty Michael Thomas3ORCID,Chen Yu2,Wang Jun1ORCID

Affiliation:

1. Department of Pharmacology and Toxicology, College of Pharmacy, The University of Arizona, Tucson, Arizona 85721, United States

2. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida 33612, United States

3. Department of Chemistry and Biochemistry, The University of Arizona, Tucson, Arizona 85721, United States

4. Department of Microbiology, Immunology and Molecular Genetics, University of Texas Health Science Center at San Antonio, San Antonio, Texas 78229, United States

Funder

Arizona Department of Health Services

National Institute of Allergy and Infectious Diseases

University of Texas Health Science Center at San Antonio

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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