Engineering of the Spinosyn PKS: Directing Starter Unit Incorporation-Reference-Cited by-同舟云学术

Engineering of the Spinosyn PKS: Directing Starter Unit Incorporation

Published:2006-12-01 Issue:12 Volume:69 Page:1702-1710
ISSN:0163-3864
Container-title:Journal of Natural Products
language:en
Short-container-title:J. Nat. Prod.

Author:

Sheehan Lesley S.¹,Lill Rachel E.¹,Wilkinson Barrie¹,Sheridan Rose M.¹,Vousden William A.¹,Kaja Andrew L.¹,Crouse Gary D.¹,Gifford James¹,Graupner Paul R.¹,Karr Laura¹,Lewer Paul¹,Sparks Thomas C.¹,Leadlay Peter F.¹,Waldron Clive¹,Martin Christine J.¹

Affiliation:

1. Biotica Technology Limited, Chesterford Research Park, Essex, CB10 1XL, U.K. Dow AgroSciences, Indianapolis, Indiana, and Department of Biochemistry, University of Cambridge, Cambridge CB2 1GA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Complementary and alternative medicine,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Analytical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/np0602517

Reference30 articles.

1. Biological Activity of the Spinosyns, New Fermentation Derived Insect Control Agents, on Tobacco Budworm (Lepidoptera: Noctuidae) Larvae

2. Rhamnose Biosynthesis Pathway Supplies Precursors for Primary and Secondary Metabolism in Saccharopolyspora spinosa

3. Cloning and analysis of the spinosad biosynthetic gene cluster of Saccharopolyspora spinosa11The DNA sequence reported here was deposited in GenBank under the accession number AY007564.

4. Heterologous expression in Saccharopolyspora erythraea of a pentaketide synthase derived from the spinosyn polyketide synthaseElectronic supplementary information (ESI) available: Further details of the construction of pCJR308, the fermentation of BIOT-0966 and the isolation of pentaketide lactone, 3, and figures showing the13C NMR and 1H COSY spectra of 3. See http://www.rsc.org/suppdata/ob/b3/b310740j/

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