Chemistry and Pharmacology of the Piperidine-Based Analogues of Cocaine. Identification of Potent DAT Inhibitors Lacking the Tropane Skeleton-Reference-Cited by-同舟云学术

Chemistry and Pharmacology of the Piperidine-Based Analogues of Cocaine. Identification of Potent DAT Inhibitors Lacking the Tropane Skeleton

Published:1998-04-28 Issue:11 Volume:41 Page:1962-1969
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Kozikowski Alan P.¹,Araldi Gian Luca¹,Boja John¹,Meil William M.¹,Johnson Kenneth M.¹,Flippen-Anderson Judith L.¹,George Clifford¹,Saiah Eddine¹

Affiliation:

1. Drug Discovery Program, Institute of Cognitive and Computational Sciences, Georgetown University Medical Center, 3970 Reservoir Road, NW, Washington, D.C. 20007-2197, Department of Pharmacology, NEOUCOM, Rootstown, Ohio 44272, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas 77555-1031, Laboratory for the Structure of Matter, Code 6030, Naval Research Laboratory, 4555 Overlook SW, Washington, D.C. 20375-5000, and Helios Pharmaceuticals, 9800 Bluegrass...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm980028%2B

Reference19 articles.

1. Kleber, H. D.; Gawin, F. H. Cocaine: Pharmacology, Effects, and Treatment of Abuse.NIDA Res. Monogr.Grabowski, J. (Ed.),1984,50, 111−129.

2. Cocaine and dopamine differentially protect [3H]mazindol binding sites from alkylation by N-ethylmaleimide

3. Delineation of discrete domains for substrate, cocaine, and tricyclic antidepressant interactions using chimeric dopamine-norepinephrine transporters.

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