Process Development of a Potent Glucosylceramide Synthase Inhibitor
Author:
Affiliation:
1. Genzyme Corporation, 153 Second Avenue, Waltham, Massachusetts 02451, United States
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op2001222
Reference22 articles.
1. Large-Scale Synthesis of the Glucosylceramide Synthase Inhibitor N-[5-(Adamantan-1-yl-methoxy)-pentyl]-1-deoxynojirimycin
2. Pharmacological Inhibition of Glucosylceramide Synthase Enhances Insulin Sensitivity
3. Hirth, B.; Rennie, G.PCT Int. Appl. 2005, in press.
4. Enhanced survival in Sandhoff disease mice receiving a combination of substrate deprivation therapy and bone marrow transplantation
5. Pathologic gene expression in Gaucher disease: up-regulation of cysteine proteinases including osteoclastic cathepsin K
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