New Insights into the Mechanism of Action of the Thienopyrimidine Antitubercular Prodrug TP053

Author:

Chiarelli Laurent R.1ORCID,Salina Elena G.2,Mori Giorgia1,Azhikina Tatyana3,Riabova Olga2,Lepioshkin Alexander2,Grigorov Artem3,Forbak Martin4,Madacki Jan4,Orena Beatrice Silvia1,Manfredi Marcello56,Gosetti Fabio7ORCID,Buzzi Arianna7,Degiacomi Giulia1,Sammartino José Camilla1,Marengo Emilio7ORCID,Korduláková Jana4,Riccardi Giovanna1,Mikušová Katarína4,Makarov Vadim2,Pasca Maria Rosalia1ORCID

Affiliation:

1. Department of Biology and Biotechnology “Lazzaro Spallanzani”, University of Pavia, via Ferrata 9, Pavia 27100, Italy

2. Bach Institute of Biochemistry, Research Center of Biotechnology of the Russian Academy of Sciences, Leninsky prospekt 33-2, Moscow 119071, Russia

3. Shemyakin and Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10, Miklukho-Maklaya Street, Moscow 117997, Russia

4. Department of Biochemistry, Faculty of Natural Sciences, Comenius University in Bratislava, Ilkovičova 6, Mlynská dolina, CH1, Bratislava SK-842 15, Slovakia

5. Department of Translational Medicine, Center for Translational Research on Autoimmune and Allergic Diseases, University of Piemonte Orientale, Corso Trieste 15, Novara 28100, Italy

6. ISALIT, Spin-off of Department of Sciences and Technological Innovation, Via A. Canobio 4/6, Novara 28100, Italy

7. Department of Sciences and Technological Innovation, University of Piemonte Orientale, Viale Teresa Michel 11, Alessandria 15121, Italy

Funder

FP7 Health

Universit? degli Studi di Pavia

Vedeck? Grantov? Agent?ra M?VVa? SR a SAV

Ministero dell?Istruzione, dell?Universit? e della Ricerca

European Regional Development Fund

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Agent?ra na Podporu V?skumu a V?voja

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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