Discovery and Characterization of the Antimetabolite Action of Thioacetamide-Linked 1,2,3-Triazoles as Disruptors of Cysteine Biosynthesis in Gram-Negative Bacteria

Author:

Wallace Miranda J.12,Dharuman Suresh1,Fernando Dinesh M.1,Reeve Stephanie M.1ORCID,Gee Clifford T.1,Yao Jiangwei3,Griffith Elizabeth C.1,Phelps Gregory A.1,Wright William C.1,Elmore John M.1,Lee Robin B.1,Chen Taosheng1ORCID,Lee Richard E.1ORCID

Affiliation:

1. Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, United States

2. Department of Microbiology, Immunology, and Biochemistry, The University of Tennessee Health Science Center, 858 Madison Avenue, Memphis, Tennessee 38163, United States

3. Department of Infectious Diseases, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee 38105, United States

Funder

St. Jude Children's Research Hospital

National Institute of Allergy and Infectious Diseases

American Lebanese Syrian Associated Charities

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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