Dronedarone Enhances the Antibacterial Activity of Polymyxin B and Inhibits the Quorum Sensing System by Interacting with LuxS

Author:

Cui Ruiqin12,Zhang Jinyong3,Liu Xiaodi4,Hu Chunxia12,Zhou Fan12,Zhang Min1,Wang Xiao5,Zou Quanming3,Huang Wei26ORCID

Affiliation:

1. Antimicrobial Drug Screening Laboratory, Shenzhen Institute of Respiratory Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, China

2. Department of Medical Laboratory, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong China

3. National Engineering Research Center of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy, Third Military Medical University, Chongqing 400038, China

4. Department of Infectious Diseases, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong China

5. Department of Pharmacy, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University, The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong China

6. Division of Hepatobiliary and Pancreas Surgery, Department of General Surgery, Shenzhen People’s Hospital, The Second Clinical Medical College, Jinan University; The First Affiliated Hospital, Southern University of Science and Technology, Shenzhen 518020, Guangdong China

Funder

National Natural Science Foundation of China

Shenzhen Key Laboratory of Pathogenic Microbiology and Antimicrobial Resistance Surveillance

Shenzhen Key Medical Discipline Construction Fund

Publisher

American Chemical Society (ACS)

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