Insights into Peptidoglycan-Targeting Radiotracers for Imaging Bacterial Infections: Updates, Challenges, and Future Perspectives

Author:

Koatale Palesa C.12,Welling Mick M.3,Ndlovu Honest12,Kgatle Mankgopo12,Mdanda Sipho12,Mdlophane Amanda12,Okem Ambrose4,Takyi-Williams John5,Sathekge Mike M.12,Ebenhan Thomas126

Affiliation:

1. Department of Nuclear Medicine, University of Pretoria, 0001 Pretoria, South Africa

2. Nuclear Medicine Research Infrastructure (NuMeRI) NPC, 0001 Pretoria, South Africa

3. Interventional Molecular Imaging Laboratory, Department of Radiology, Leiden University Medical Center, 2333 ZA Leiden, The Netherlands

4. Department of Anaesthesia, School of Clinical Medicine, University of Witwatersrand, 2050 Johannesburg, South Africa

5. Pharmacokinetic and Mass Spectrometry Core, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States

6. DSI/NWU Pre-clinical Drug Development Platform, North West University, 2520 Potchefstroom, South Africa

Funder

Ernest Oppenheimer Memorial Trust

National Research Foundation

Nuclear Medicine Research Infrastructure NPC

Publisher

American Chemical Society (ACS)

Reference154 articles.

1. Multidrug-Resistant Bacterial Infections in U.S. Hospitalized Patients, 2012–2017

2. A broad spectrum anti-bacterial peptide with an adjunct potential for tuberculosis chemotherapy

3. O’Neill, J. Antimicrobial Resistance: Tackling a Crisis for the Health and Wealth of Nations. In: The Review on Antimicrobial Resistance London, 2014; pp 1–20. Available from https://amr-review.org/.

4. O’Neill, J. Review on Antimicrobial Resistance: Tackling Drug-Resistant Infections Globally: Final Report and Recommendations, 2016; pp 1–20. Available from: https://amr-review.org/background.html.

5. The Promise of Molecular Imaging in the Study and Treatment of Infectious Diseases

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