1,3-Diarylpyrazolyl-acylsulfonamides Target HadAB/BC Complex in Mycobacterium tuberculosis

Author:

Singh Vinayak12ORCID,Grzegorzewicz Anna E.3,Fienberg Stephen1,Müller Rudolf1,Khonde Lutete Peguy1,Sanz Olalla4,Alfonso Salvatore4,Urones Beatriz4,Drewes Gerard5,Bantscheff Marcus5ORCID,Ghidelli-Disse Sonja5,Ioerger Thomas R.6,Angala Bhanupriya3,Liu Jiuyu7,Lee Richard E.7ORCID,Sacchettini James C.8ORCID,Krieger Inna V.8,Jackson Mary3ORCID,Chibale Kelly12ORCID,Ghorpade Sandeep R.1ORCID

Affiliation:

1. Drug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch7701, South Africa

2. South African Medical Research Council Drug Discovery and Development Research Unit, Department of Chemistry and Institute of Infectious Disease and Molecular Medicine, University of Cape Town, Rondebosch7701, South Africa

3. Mycobacteria Research Laboratories, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado80523-1682, United States;

4. Global Health Pharma Research Unit, GlaxoSmithKline, Severo Ochoa 2, Tres Cantos, Madrid28760, Spain

5. Cellzome GmbH · A GSK Company, Meyerhofstrasse 1, Heidelberg69117, Germany

6. Department of Computer Science and Engineering, Texas A&M University, College Station, Texas77843, United States

7. Department of Chemical Biology & Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Memphis, Tennessee38105, United States;

8. Texas A&M University, Department of Biochemistry and Biophysics, ILSB 2138, 301 Old Main Dr, College Station, Texas77843-3474, United States

Funder

Welch Foundation

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

University of Cape Town

Department of Science and Innovation, South Africa

South African Medical Research Council

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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