Fast-Killing Tyrosine Amide ((S)-SW228703) with Blood- and Liver-Stage Antimalarial Activity Associated with the Cyclic Amine Resistance Locus (PfCARL)

Author:

Imlay Leah S.ORCID,Lawong Aloysus K.,Gahalawat Suraksha,Kumar AshwaniORCID,Xing ChaoORCID,Mittal Nimisha1,Wittlin Sergio23ORCID,Churchyard Alisje4,Niederstrasser Hanspeter,Crespo-Fernandez Benigno5ORCID,Posner Bruce A.,Gamo Francisco-Javier5ORCID,Baum Jake46,Winzeler Elizabeth A.1ORCID,Laleu Benoît7ORCID,Ready Joseph M.ORCID,Phillips Margaret A.ORCID

Affiliation:

1. Division of Host-Microbe Systems and Therapeutics, Department of Pediatrics, University of California San Diego, La Jolla, California 92093, United States

2. Swiss Tropical and Public Health Institute, 4002 Basel, Switzerland

3. University of Basel, 4002 Basel, Switzerland

4. Department of Life Sciences, Imperial College London, London SW7 2AZ, U.K.

5. Global Health Medicines, GlaxoSmithKline R&D, Tres Cantos, 28760 Madrid, Spain

6. School of Biomedical Sciences, University of New South Wales, Kensington, NSW 2052, Australia

7. Medicines for Malaria Venture, 1215 Geneva 15, Switzerland

Funder

Welch Foundation

National Institute of Allergy and Infectious Diseases

Wellcome Trust

Medicines for Malaria Venture

National Institute of General Medical Sciences

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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