Durlobactam, a Diazabicyclooctane β-Lactamase Inhibitor, Inhibits BlaC and Peptidoglycan Transpeptidases of Mycobacterium tuberculosis

Author:

Nantongo Mary12ORCID,Nguyen David C.3ORCID,Bethel Christopher R.2,Taracila Magdalena A.24,Li Qing4,Dousa Khalid M.245,Shin Eunjeong24,Kurz Sebastian G.6,Nguyen Liem1,Kreiswirth Barry N.7,Boom W. Henry14,Plummer Mark S.8,Bonomo Robert A.145910ORCID

Affiliation:

1. Department of Molecular Biology and Microbiology, Case Western Reserve University (CWRU), Cleveland, Ohio 44106, United States

2. Research Service, Louis Stokes Veterans Affairs Medical Center, Cleveland, Ohio 44106, United States

3. Division of Infectious Diseases, Department of Pediatrics and Division of Infectious Diseases, and Department of Internal Medicine, Rush University Medical Center, Chicago, Illinois 60612, United States

4. Department of Medicine, Case Western Reserve University (CWRU), Cleveland, Ohio 44106, United States

5. Medical Service, Veterans Affairs Northeast Ohio Healthcare System (VANEOHS), Cleveland, Ohio 44106, United States

6. Department of Internal Medicine VIII, Medical Oncology and Pneumology, University of Tübingen, 72076 Tübingen, Germany

7. Center for Discovery and Innovation, Hackensack, New Jersey 07110, United States

8. Biopharmaworks, Groton, Connecticut 06340, United States

9. CWRU-Cleveland VAMC Center for Antibiotic Resistance and Epidemiology (Case VA CARES), Cleveland, Ohio 44106, United States

10. Departments of Biochemistry, Pharmacology, and Proteomics and Bioinformatics, CWRU, Cleveland, Ohio 44106, United States

Funder

Fogarty International Center

Division of Microbiology and Infectious Diseases

Publisher

American Chemical Society (ACS)

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