Discovery and Biosynthesis of Persiathiacins: Unusual Polyglycosylated Thiopeptides Active Against Multidrug Resistant Tuberculosis

Author:

Dashti Yousef12ORCID,Mohammadipanah Fatemeh3ORCID,Zhang Yu1,Cerqueira Diaz Pietra M.1,Vocat Anthony4,Zabala Daniel1,Fage Christopher D.1ORCID,Romero-Canelon Isolda15ORCID,Bunk Boyke67,Spröer Cathrin67,Alkhalaf Lona M.1ORCID,Overmann Jörg678,Cole Stewart T.4,Challis Gregory L.191011ORCID

Affiliation:

1. Department of Chemistry, University of Warwick, Coventry CV4 7AL, U.K.

2. Sydney Infectious Diseases Institute, Faculty of Medicine and Health, University of Sydney, Sydney NSW 2015, Australia

3. Pharmaceutical Biotechnology Lab, School of Biology and Center of Excellence in Phylogeny of Living Organisms, College of Science, University of Tehran, 14155-6455 Tehran, Iran

4. Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Station 19, 1015 Lausanne, Switzerland

5. School of Pharmacy, Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, U.K.

6. Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, 38124 Braunschweig, Germany

7. Technical University of Braunschweig, 38106 Braunschweig, Germany

8. German Centre of Infection Research (DZIF), Partner Site Hannover-Braunschweig, 38124 Braunschweig, Germany

9. Warwick Integrative Synthetic Biology Centre, University of Warwick, Coventry CV4 7AL, U.K.

10. Department of Biochemistry and Molecular Biology, Monash University, Clayton VIC 3168, Australia

11. ARC Centre of Excellence for Innovations in Peptide and Protein Science, Monash University, Clayton VIC 3168, Australia

Funder

Royal Society

Research Councils UK

Biotechnology and Biological Sciences Research Council

Publisher

American Chemical Society (ACS)

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