Synthesis and Anti-Chagas Activity Profile of a Redox-Active Lead 3-Benzylmenadione Revealed by High-Content Imaging

Author:

Trometer Nathan1,Pecourneau Jérémy1,Feng Liwen1,Navarro-Huerta José A.1,Lazarin-Bidóia Danielle2,de Oliveira Silva Lautenschlager Sueli2,Maes Louis3,Fortes Francisco Amanda4,Kelly John M.4ORCID,Meunier Brigitte5,Cal Monica67,Mäser Pascal67ORCID,Kaiser Marcel67,Davioud-Charvet Elisabeth1ORCID

Affiliation:

1. UMR7042 CNRS-Unistra-UHA, Laboratoire d’Innovation Moléculaire et Applications (LIMA), Bio(in)organic & Medicinal Chemistry Team, European School of Chemistry, Polymers and Materials (ECPM), 25, rue Becquerel, F-67087 Strasbourg, France

2. Laboratório de Inovação Tecnológica no Desenvolvimento de Fármacos e Cosméticos, Departamento de Ciências Básicas da Saúde, Universidade Estadual de Maringá, CEP 87020-900 Paraná, Brazil

3. Laboratory of Microbiology, Parasitology and Hygiene (LMPH), Faculty of Pharmaceutical, Biomedical and Veterinary Sciences, University of Antwerp, CDE-S7.27 Universiteitsplein 1, B-2610 Antwerp, Belgium

4. Department of Infection Biology, London School of Hygiene & Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom

5. Institute for Integrative Biology of the Cell (I2BC), CEA, CNRS, Univ. Paris-Sud, Université Paris-Saclay, F-91198 Gif-sur-Yvette cedex, France

6. Swiss Tropical and Public Health Institute, Kreuzstrasse 2, CH-4123 Allschwil, Switzerland

7. University of Basel, Petersgraben 1, CH-4001 Basel, Switzerland

Funder

Agence Nationale de la Recherche

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Europäische Konföderation der Oberrheinischen Universitäten

Publisher

American Chemical Society (ACS)

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