The Enzymatic Activity of Inosine 5′-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections

Author:

Modi Gyan1,Marqus Gary M.2,Vippila Mohana Rao3,Gollapalli Deviprasad R.1,Kim Youngchang45,Manna Adhar C.6,Chacko Shibin1,Maltseva Natalia45,Wang Xingyou2,Cullinane Ryan T.7,Zhang Yubo7,Kotler Judy L. M.8,Kuzmic Petr9,Zhang Minjia1,Lawson Ann P.1,Joachimiak Andrzej4510,Cheung Ambrose6,Snider Barry B.11ORCID,Rothstein David M.12,Cuny Gregory D.3ORCID,Hedstrom Lizbeth111ORCID

Affiliation:

1. Department of Biology, Brandeis University, Waltham, Massachusetts 02453, United States

2. Graduate Program in Chemistry, Brandeis University, Waltham Massachusetts 02453, United States

3. Department of Pharmacological and Pharmaceutical Sciences, College of Pharmacy, University of Houston, Health Building 2, 4849 Calhoun Rd., Houston, Texas 77204, United States

4. Center for Structural Genomics of Infectious Diseases, Consortium for Advanced Science and Engineering, University of Chicago, Chicago, Illinois 60667, United States

5. The Structural Biology Center, X-ray Science Division, Argonne National Laboratory, Lemont, Illinois 60439, United States

6. Department of Microbiology and Immunology, Geisel School of Medicine at Dartmouth, Hanover, New Hampshire 03755, United States

7. Department of Biochemistry, Brandeis University, Massachusetts 02453, United States

8. Graduate Program in Biochemistry and Biophysics, Brandeis University, Waltham, Massachusetts 02453, United States

9. BioKin Ltd., Watertown, Massachusetts 02472, United States

10. Department of Biochemistry and Molecular Biology, University of Chicago, Chicago, Illinois 60367, United States

11. Department of Chemistry, Brandeis University, Waltham, Massachusetts 02453, United States

12. David Rothstein Consulting, LLC, Lexington, Massachusetts 02421, United States

Funder

National Institute of Allergy and Infectious Diseases

U.S. Department of Energy

Brandeis University

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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