Structure, In Vivo Detection, and Antibacterial Activity of Metabolites of SQ109, an Anti-Infective Drug Candidate-Reference-Cited by-同舟云学术

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Structure, In Vivo Detection, and Antibacterial Activity of Metabolites of SQ109, an Anti-Infective Drug Candidate

Published:2021-07-19 Issue:8 Volume:7 Page:2492-2507
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Malwal Satish R.¹^ORCID,Zimmerman Matthew D.²,Alvarez Nadine²,Sarathy Jansy P.²,Dartois Véronique²³^ORCID,Nacy Carol A.⁴,Oldfield Eric¹^ORCID

Affiliation:

1. Department of Chemistry, University of Illinois at Urbana−Champaign, Urbana, Illinois 61801, United States

2. Center for Discovery and Innovation, 111 Ideation Way, Nutley, New Jersey 07110, United States

3. Hackensack School of Medicine, Department of Medical Sciences, 123, Metro Boulevard, Nutley, New Jersey 07110, United States

4. Sequella, Inc., 9610 Medical Center Drive, Suite 200, Rockville, Maryland 20850, United States

Funder

U.S. Department of Health and Human Services

University of Illinois

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00259

Reference41 articles.

1. World Health Organization. Global Tuberculosis Report 2019; World Health Organization: Geneva, Switzerland, 2019.

2. MDR/XDR-TB management of patients and contacts: Challenges facing the new decade. The 2020 clinical update by the Global Tuberculosis Network

3. Identification of a new antitubercular drug candidate, SQ109, from a combinatorial library of 1,2-ethylenediamines

4. Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action

5. SQ109 Targets MmpL3, a Membrane Transporter of Trehalose Monomycolate Involved in Mycolic Acid Donation to the Cell Wall Core of Mycobacterium tuberculosis

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1. Inhibition Mechanism of Anti-TB Drug SQ109: Allosteric Inhibition of TMM Translocation of Mycobacterium Tuberculosis MmpL3 Transporter;Journal of Chemical Information and Modeling;2023-08-17

2. Manipulation of Bacterial ROS Production Leads to Self-escalating DNA Damage and Resistance-resistant Lethality for Intracellular Mycobacteria;2023-07-07

3. Recent advances in mycobacterial membrane protein large 3 inhibitor drug design for mycobacterial infections;Expert Opinion on Drug Discovery;2023-06-04

4. Investigation into the Mechanism of Action of the Tuberculosis Drug Candidate SQ109 and Its Metabolites and Analogues in Mycobacteria;Journal of Medicinal Chemistry;2023-05-26

5. Study of SQ109 analogs binding to mycobacterium MmpL3 transporter using MD simulations and alchemical relative binding free energy calculations;Journal of Computer-Aided Molecular Design;2023-05-02

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