Cytochrome P450-Mediated Metabolism and CYP Inhibition for the Synthetic Peroxide Antimalarial OZ439

Author:

Shackleford David M.1,Chiu Francis C. K.1,Katneni Kasiram1,Blundell Scott1,McLaren Jenna1,Wang Xiaofang2,Zhou Lin2,Sriraghavan Kamaraj2,Alker André M.3,Hunziker Daniel3,Scheurer Christian45,Zhao Qingjie2,Dong Yuxiang2ORCID,Möhrle Jörg J.6,Abla Nada6,Matile Hugues3,Wittlin Sergio45,Vennerstrom Jonathan L.2ORCID,Charman Susan A.1ORCID

Affiliation:

1. Centre for Drug Candidate Optimisation, Monash Institute of Pharmaceutical Sciences, Monash University (Parkville Campus), 381 Royal Parade, Parkville, Victoria 3052, Australia

2. College of Pharmacy, University of Nebraska Medical Center, 986125 Nebraska Medical Center, Omaha, Nebraska 68198, United States

3. Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Grenzacherstrasse 124, CH-4070 Basel, Switzerland

4. Swiss Tropical and Public Health Institute, Socinstrasse 57, CH-4002 Basel, Switzerland

5. University of Basel, CH-4003 Basel, Switzerland

6. Medicines for Malaria Venture, 20 Route de Pré-Bois, CH-1215 Geneva 15, Switzerland

Funder

Medicines for Malaria Venture

Nebraska Research Initiative

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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