Structure-Based Design of α-Substituted Mercaptoacetamides as Inhibitors of the Virulence Factor LasB from Pseudomonas aeruginosa

Author:

Kaya Cansu12,Walter Isabell12,Alhayek Alaa12,Shafiei Roya12ORCID,Jézéquel Gwenaëlle1ORCID,Andreas Anastasia12,Konstantinović Jelena1,Schönauer Esther3ORCID,Sikandar Asfandyar1,Haupenthal Jörg1,Müller Rolf124ORCID,Brandstetter Hans3,Hartmann Rolf W.12ORCID,Hirsch Anna K.H.124ORCID

Affiliation:

1. Helmholtz Institute for Pharmaceutical Research Saarland (HIPS)─Helmholtz Centre for Infection Research (HZI), Campus E8.1, 66123 Saarbrücken, Germany

2. Department of Pharmacy, Saarland University, Campus E8.1, 66123 Saarbrücken, Germany

3. Department of Biosciences and Medical Biology, University of Salzburg, Hellbrunner Straße, 34, 5020 Salzburg, Austria

4. Helmholtz International Lab for Anti-Infectives, Campus E 8.1, 66123 Saarbrücken, Germany

Funder

Austrian Science Fund

Alexander von Humboldt-Stiftung

Helmholtz Association

CARB-X

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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