Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA-Reference-Cited by-同舟云学术

Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-cholest-4,22-dien-24-oyl-CoA

Published:2021-04-07 Issue:6 Volume:7 Page:1739-1751
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Yuan Tianao¹^ORCID,Werman Joshua M.¹^ORCID,Yin Xingyu²^ORCID,Yang Meng¹^ORCID,Garcia-Diaz Miguel³^ORCID,Sampson Nicole S.¹^ORCID

Affiliation:

1. Department of Chemistry, Stony Brook University, Stony Brook, New York 11794-3400, United States

2. Biochemistry and Structural Biology Graduate Program, Stony Brook University, Stony Brook, New York 11794-5215, United States

3. Department of Pharmacological Sciences, Stony Brook University, Stony Brook, New York 11794-8651, United States

Funder

National Institute of Allergy and Infectious Diseases

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00069

Reference49 articles.

1. World Health Organization. Global tuberculosis report 2020. https://apps.who.int/iris/bitstream/handle/10665/336069/9789240013131-eng.pdf (accessed 7 February 2021).

2. The pursuit of mechanism of action: uncovering drug complexity in TB drug discovery

3. Metabolomics of Mycobacterium tuberculosis Reveals Compartmentalized Co-Catabolism of Carbon Substrates

4. Integration of Metabolomics and Transcriptomics Reveals a Complex Diet of Mycobacterium tuberculosis during Early Macrophage Infection

5. Mycobacterial persistence requires the utilization of host cholesterol

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