Discovery of a Tricyclic β-Lactam as a Potent Antimicrobial Agent against Carbapenem-Resistant Enterobacterales, Including Strains with Reduced Membrane Permeability and Four-Amino Acid Insertion into Penicillin-Binding Protein 3: Structure–Activity-Relationships and <i>In Vitro</i> and <i>In Vivo</i> Activities-Reference-Cited by-同舟云学术

Discovery of a Tricyclic β-Lactam as a Potent Antimicrobial Agent against Carbapenem-Resistant Enterobacterales, Including Strains with Reduced Membrane Permeability and Four-Amino Acid Insertion into Penicillin-Binding Protein 3: Structure–Activity-Relationships and In Vitro and In Vivo Activities

Published:2022-02-03 Issue:3 Volume:8 Page:400-410
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Sato Jun¹^ORCID,Kusano Hiroki¹,Aoki Toshiaki²,Shibuya Satoru¹,Yokoo Katsuki¹,Komano Kazuo¹,Oguma Takuya¹^ORCID,Matsumoto Shuhei³,Nakamura Rio⁴,Sato Takafumi¹,Yamawaki Kenji¹

Affiliation:

1. Shionogi Pharmaceutical Research Center, Toyonaka-shi, Osaka 561-0825, Japan

2. Shionogi CMC Research Innovation Center, Amagasaki-shi, Hyogo 660-0813, Japan

3. Shionogi, Head Office, 1-8, Doshomachi 3-chome, Chuo-ku, Osaka 541-0045, Japan

4. Shionogi TechnoAdvance Research Co., Ltd., Toyonaka-shi, Osaka 561-0825, Japan

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.1c00549

Reference33 articles.