In Vivo Activity of Repurposed Amodiaquine as a Host-Targeting Therapy for the Treatment of Anthrax

Author:

Martchenko Shilman Mikhail12ORCID,Bartolo Gloria1,Alameh Saleem1,Peterson Johnny W.3,Lawrence William S.3,Peel Jennifer E.3,Sivasubramani Satheesh K.4,Beasley David W. C.3,Cote Christopher K.5,Demons Samandra T.5,Halasahoris Stephanie A.5,Miller Lynda L.5,Klimko Christopher P.5,Shoe Jennifer L.5,Fetterer David P.6,McComb Ryan1,Ho Chi-Lee C.7,Bradley Kenneth A.7,Hartmann Stella1,Cheng Luisa W.8,Chugunova Marina9,Kao Chiu-Yen10,Tran Jennifer K.1,Derbedrossian Aram1,Zilbermintz Leeor1,Amali-Adekwu Emiene1,Levitin Anastasia1ORCID,West Joel12

Affiliation:

1. Henry E. Riggs School of Applied Life Sciences, Keck Graduate Institute (KGI), 535 Watson Drive, Claremont, California 91711, United States

2. Shield Pharma LLC, 1420 North Claremont Boulevard, Suite 102A, Claremont, California 91711, United States

3. Department of Microbiology and Immunology, University of Texas Medical Branch (UTMB), 301 University Boulevard, Galveston, Texas 77555, United States

4. Directorate of Environmental Health Effects Laboratory, Naval Medical Research Unit, Wright-Patterson Air Force Base, 2728 Q Street, Building 837, Wright-Patterson AFB, Ohio 45433, United States

5. Bacteriology Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States

6. Biostatistics Division, U.S. Army Medical Research Institute of Infectious Diseases (USAMRIID), 1425 Porter Street, Fort Detrick, Maryland 21702, United States

7. Department of Microbiology, Immunology and Molecular Genetics, University of California, Los Angeles (UCLA), 609 Charles E. Young Drive East, Los Angeles, California 90095, United States

8. Foodborne Toxin Detection and Prevention Research Unit, Western Regional Research Center, United States Department of Agriculture (USDA), 800 Buchanan Street, Albany, California 94710, United States

9. Institute of Mathematical Sciences, Claremont Graduate University (CGU), 150 East 10th Street, Claremont, California 91711, United States

10. Department of Mathematical Sciences, Claremont McKenna College (CMC), 888 North Columbia Avenue, Claremont, California 91711, United States

Funder

Comprehensive Cancer Center, City of Hope

National Institute of Allergy and Infectious Diseases

Defense Threat Reduction Agency

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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