DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in <i>Mycobacterium tuberculosis</i>-Reference-Cited by-同舟云学术

DNA-Dependent Binding of Nargenicin to DnaE1 Inhibits Replication in Mycobacterium tuberculosis

Published:2022-02-10 Issue:3 Volume:8 Page:612-625
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Chengalroyen Melissa D.¹,Mason Mandy K.¹,Borsellini Alessandro²,Tassoni Raffaella²,Abrahams Garth L.¹³,Lynch Sasha¹,Ahn Yong-Mo³,Ambler Jon⁴,Young Katherine⁵,Crowley Brendan M.⁶,Olsen David B.⁵,Warner Digby F.¹^ORCID,Barry III Clifton E.³,Boshoff Helena I. M.³^ORCID,Lamers Meindert H.²,Mizrahi Valerie¹^ORCID

Affiliation:

1. SAMRC/NHLS/UCT Molecular Mycobacteriology Research Unit, DST/NRF Centre of Excellence for Biomedical TB Research, Institute of Infectious Disease and Molecular Medicine and Department of Pathology, Faculty of Health Sciences, University of Cape Town, Anzio Road, Observatory 7925, South Africa

2. Cell and Chemical Biology, Leiden University Medical Center, Einthovenweg 20, 2333 ZC Leiden, The Netherlands

3. Tuberculosis Research Section, Laboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Disease, National Institutes of Health, 9000 Rockville Pike, Bethesda, Maryland 20892, United States

4. Wellcome Centre for Infectious Diseases Research in Africa, University of Cape Town, Anzio Road, Observatory 7925, South Africa

5. Infectious Disease, Merck & Co. Inc., West Point, Pennsylvania 19446, United States

6. Discovery Chemistry, Merck & Co. Inc., West Point, Pennsylvania 19446, United States

Funder

Howard Hughes Medical Institute

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

South African Agency for Science and Technology Advancement

Ernest Oppenheimer Memorial Trust

Broad Institute

South African Medical Research Council

Crick African Network