An “Unlikely” Pair: The Antimicrobial Synergy of Polymyxin B in Combination with the Cystic Fibrosis Transmembrane Conductance Regulator Drugs KALYDECO and ORKAMBI

Author:

Schneider Elena K.1,Azad Mohammad A. K.1,Han Mei-Ling1,(Tony) Zhou Qi2,Wang Jiping1,Huang Johnny X.3,Cooper Matthew A.3,Doi Yohei4,Baker Mark A.5,Bergen Phillip J.6,Muller Mark T.7,Li Jian1,Velkov Tony1

Affiliation:

1. Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

2. Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, 575 West Stadium Avenue, West Lafayette, Indiana 47907-2091, United States

3. Institute for Molecular Bioscience, The University of Queensland, St Lucia, Queensland 4072, Australia

4. Division of Infectious Diseases, Department of Medicine, University of Pittsburgh Medical Center, Liliane S. Kaufmann Building, 3471 Fifth Avenue, Pittsburgh, Pennsylvania 15213, United States

5. Priority Research Centre in Reproductive Science, School of Environmental and Life Sciences, University of Newcastle, Callaghan, New South Wales 2308, Australia

6. Center for Medicine Use and Safety, Monash University, 381 Royal Parade, Parkville, Victoria 3052, Australia

7. Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, 6900 Lake Nona Boulevard, Orlando, Florida 32816, United States

Funder

National Institute of Allergy and Infectious Diseases

National Health and Medical Research Council

Cystic Fibrosis Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

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