Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product-Reference-Cited by-同舟云学术

Discovery of Potent Pantothenamide Inhibitors of Staphylococcus aureus Pantothenate Kinase through a Minimal SAR Study: Inhibition Is Due to Trapping of the Product

Published:2016-08-03 Issue:9 Volume:2 Page:627-641
ISSN:2373-8227
Container-title:ACS Infectious Diseases
language:en
Short-container-title:ACS Infect. Dis.

Author:

Hughes Scott J.,Barnard Leanne¹,Mottaghi Katayoun,Tempel Wolfram,Antoshchenko Tetyana²,Hong Bum Soo,Allali-Hassani Abdellah,Smil David,Vedadi Masoud,Strauss Erick¹,Park Hee-Won²

Affiliation:

1. Department of Biochemistry, Stellenbosch University, Stellenbosch 7600, South Africa

2. Department of Biochemistry and Molecular Biology, Tulane School of Medicine, New Orleans, Louisiana 70112, United States

Funder

Congressionally Directed Medical Research Programs

Wellcome Trust

Louisiana Board of Regents

National Research Foundation

Structural Genomics Consortium

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Link

https://pubs.acs.org/doi/pdf/10.1021/acsinfecdis.6b00090

Reference56 articles.

1. Frieden, T. (2013) InAntibiotic Resistance Threats in the United States,CDC, Atlanta, GA, USA.

2. Challenges of Antibacterial Discovery

3. New treatment options against gram-negative organisms

4. Current Concepts in Antimicrobial Therapy Against Select Gram-Positive Organisms: Methicillin-ResistantStaphylococcus aureus, Penicillin-Resistant Pneumococci, and Vancomycin-Resistant Enterococci

5. New insights into meticillin-resistant Staphylococcus aureus (MRSA) pathogenesis, treatment and resistance

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