Structure of the Essential Mtb FadD32 Enzyme: A Promising Drug Target for Treating Tuberculosis

Author:

Kuhn Misty L.12,Alexander Evan,Minasov George1,Page Holland J.2,Warwrzak Zdzislaw3,Shuvalova Ludmilla1,Flores Kristin J.1,Wilson Daniel J.,Shi Ce,Aldrich Courtney C.,Anderson Wayne F.1

Affiliation:

1. Center for Structural Genomics of Infectious Diseases, Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, United States

2. Department of Chemistry and Biochemistry, San Francisco State University, San Francisco, California 94132, United States

3. LS-CAT, Synchrotron Research Center, Northwestern University, Argonne, Illinois 60439, United States

Funder

San Francisco State University

National Institute of Allergy and Infectious Diseases

Bill and Melinda Gates Foundation

Publisher

American Chemical Society (ACS)

Subject

Infectious Diseases

Reference46 articles.

1. WHO | Tuberculosismortality nearly halved since 1990. http://www.who.int/mediacentre/news/releases/2015/tuberculosis-mortality/en/(accessed May 11, 2016) .

2. Heterogeneity in tuberculosis pathology, microenvironments and therapeutic responses

3. The path of anti-tuberculosis drugs: from blood to lesions to mycobacterial cells

4. The Sculpting of the Mycobacterium tuberculosis Genome by Host Cell–Derived Pressures

5. WHO | Antimicrobial resistance: globalreport on surveillance 2014. http://www.who.int/drugresistance/documents/surveillancereport/en/(accessed May 11, 2016) .

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